But defending champion Marc Marquez and iconic veteran Valentino Rossi will also be eying victory. The reigning world champion continued his domination on the American soil as he cruised to his sixth successive win in Austin.
"I went out, and unfortunately I didn't expect Maverick to arrive behind me because I was focused on Andrea (Iannone), who was waiting ahead and who I knew could be very fast", Marquez said.
Compatriot Maverick Vinales, who had started on pole position for Yamaha, finished second and 3.5 seconds behind Marquez while Suzuki's Italian Andrea Iannone was third. However, given Marquez's supreme pace over the whole weekend, it was not much of deterrent to the Repsol Honda rider.
A great start saw Marquez jump toward the front through the first turn and he had the lead halfway through the first lap.
After losing touch with Marquez, Iannone soon came under pressure from Vinales, who made a move for second at Turn 1 on the seventh lap and enjoyed an untroubled run to the runner-up spot after that.
It was mostly status quo for the rest of the race apart from a few fallers including championship leader Cal Crutchlow.
Rossi was a distant fourth in the end, while Dovizioso got the better of Tech3's Johann Zarco in the closing stages to take fifth and a slender one-point lead in the standings ahead of Marquez.
Marquez's Spanish team mate Dani Pedrosa, who had surgery on a broken wrist last week after crashing in Argentina, will start ninth on the grid.
Completing the top 10 were privateer Ducati pair Tito Rabat (Avintia) and Jack Miller (Pramac) and the leading Aprilia of Aleix Espargaro, who all crowded past a struggling Jorge Lorenzo (Ducati) late on. He qualified on pole but was demoted to 4th for blocking Maverick Vinales.