Yohan Blake stormed into Monday's Commonwealth Games 100 metres final spurred by a message from Usain Bolt, who told his fellow Jamaican: "You've got to win".
Ahye is the second athlete from here country to take gold in the event, after Ato Bolden, victor of the men's race at the 1998 Kuala Lumpur Games with a record time of 9.88s.
He had run 10.06sec in the semi-finals to be the fastest qualifier into the final.
Alongside the likes of Canada's Andre de Grasse and Christian Coleman, of the United States, Simbine represents the future of global sprinting and he took a significant scalp on the way to victory in the Gold Coast by beating Yohan Blake, the second fastest man in history.
South Africa's Akani Simbine dealt with the egos as he upset one of the biggest drawcards of the Commonwealth Games to take a shock gold in the men's 100m.
Immediately after the race, Bolt reached out to his former training partner, tweeting: "Well done @YohanBlake".
"Well done @YohanBlake. Keep putting in the work. You know your journey". That followed a 10.15 in his opening heat on the first afternoon of the track and field competition.
It was the first time in 20 years the 100m crown was not retained by a Caribbean nation.
Blake recovered well enough to claim the bronze in 10.19.
Gymnast Marios Georgiou led the gold rush with his third medal on the Gold Coast - in the men's parallel bars - while Georgios Achilleos came out on top in the men's skeet shooting final to continue the nation's push for a record-breaking Games.
"It's a milestone and a stepping-stone towards world championships and the Olympics".
So often the bridesmaid at major events in the past, Ahye controlled Monday's race to win in 11.14 ahead of Jamaicans Christania Williams and Gayon Evans.
The final was without its main drawcards with Olympic champion Elaine Thompson electing to focus only on the 200m.
"It's my first global title and for me it's a milestone, a stepping stone towards the world championships, and the Olympics and more competitions and more worldwide competitions", said Simbine, adding he needed to call his mother watching back home in South Africa.
After the race, Blake admitted he may have underestimated his rivals.
The performance of third placegetter Bruintjies had an Australian twist given he only made the final at the expense of Rohan Browning.
Olympic champion Max Whitlock of England stumbled to sixth in the men's floor gymnastics competition, which was won by Marios Georgiou of Cyprus.
Simbine now puts his name in the mix as a replacement for Bolt.
Bolt, who retired previous year with eight Olympic golds including two 4x100 relay titles shared with Blake, tweeted his congratulations to his team mate and Simbine.
Ali often referred to himself as "the greatest", and after completing an unprecedented triple-triple at the Rio Olympics in 2016, Bolt declared "that's it, I'm the greatest".
Both Van Njekerk and De Grasse were expected to be on the Gold Coast but injuries caused them to miss.