Nevada's only previous regional semifinal appearance came in 2004.
Nevada's comeback win against Cincinnati is going into the record book.
Trailing 65-43 with 11:34 left, the Wolf Pack rallied to earn the second-biggest comeback win in NCAA tournament history.
Josh Hall collected an offensive rebound and scored on a short jump shot with 10 seconds left to break a 73-73 tie, and the Bearcats couldn't get a shot off in the final seconds. The final score was 75-73, the result of one of the greatest tournament comebacks ever (and Nevada's second huge comeback in as many games).
Cody Martin had 25 points, seven assists and six rebounds.
Barry Brown scored 18 points, and Kansas State ended UMBC's brief, but historic run in the NCAA Tournament with a victory.
Cincinnati's Cane Broome raced up the court, briefly lost control of the ball and then appeared to try putting up a shot that Nevada's Caleb Martin knocked away.
Nevada faces No. 11 Loyola Chicago at 7:07 p.m. Thursday in an Elite Eight matchup at Philips Arena in Atlanta. Nevada has trailed at halftime in five straight games and is still in the Sweet 16. They overcame a 14-point deficit in the second half of the first-round match-up against Texas.
The Bearcats had the Wolf Pack on the ropes, up 22 points with about 11 minutes to play.
With the game tied in the closing seconds, Hall got a rebound off a missed shot by Cody Martin. ESPN said that's the first time a region has failed to have a top-four team in the Sweet 16 since seeding began in 1979.