The biggest surprise of the day was the defeat of former world number one, Serbian Novak Djokovic, who returned to the tournament following his elbow operation, only to be defeated by Japanese Taro Daniel, ranked 109th in the world, 7-6 (3), 4-6, 6-1.
On the women's side, top-ranked Simona Halep came back to top 19-year-old Caroline Dolehide 1-6, 7-6 (3), 6-2 in just over two hours.
Reigning World No.1 Roger Federer of Switzerland completed his match against Argentina's Federico Delbonis, suspended a day earlier, and advanced to the third round of the Indian Wells tennis tournament with a 6-3, 7-6 (6) win.
Federer stressed it was always going to be hard for the six-time Australian victor to impress on his return from injury, which is why the 36-year-old was not surprised following Djokovic's struggle in Indian Wells. He then made a decision to stop and have an operation to heal his elbow injury.
Federer will now face 25th seed Filip Krajinovic in the third round. Find us on Facebook too!
He is making a cautious return to the ATP Tour after stopping his 2017 season following Wimbledon, due to a right elbow injury.
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"For me it felt like first match I ever played on the tour". "I mean, I just completely lost rhythm, everything".
Djokovic shut down his season after Wimbledon in 2017 and despite not being at his best, chose to play at this year's Australian Open where he was ousted by South Korea's Hyeon Chung in the fourth round.
"To me, it's not that surprising", Federer said. "When you go away from the game for over a two-month period, it starts feeling a little bit that way", the Express quoted Federer as saying.
He will now play against another American, Jack Sock, who beat Italy's Thomas Fabbiano 6-2, 7-5.
Other seeded players who lost were ninth-seeded Lucas Pouille, who fell 6-4, 6-4 to Yuki Bhambri; 14th-seeded Diego Schwartzman, 7-5, 6-4 to Marcos Baghdatis; 21st-seeded Kyle Edmund, 6-4, 6-4 to Dudi Sela; and No. 24 seed Giles Muller, 6-3, 7-5 to Pierre-Hugues Herbert.