The storm is expected to drop about a foot of snow or more in some areas by the time it moves eastward out of the region Friday night.
"The snow is here and we can expect anywhere from 4"-7", 5"-9", or even up to 10" of snow in Ingham County.
Accumulating snow is also expected across Livingston, Monroe and Ontario counties this afternoon through tonight "during which time there could be enough snow to warrant winter weather advisories", the Weather Service said.
Forecasts show an 80 percent chance for snow persists on Saturday night and on Sunday as well. Classes were also canceled in the city's suburbs.
In Michigan, forecasters were predicting six to nine inches this weekend for Detroit's Wayne County and Ann Arbor's Washtenaw County, according to the Detroit Free Press.
"Snow totals will still come close to a foot, and at this point, I wouldn't be surprised to see a few 15" totals because of how hard it's snowed for so long. By early Friday, more than 100 flights were canceled at Detroit Metropolitan Airport in Romulus, Michigan. CPS officials say they anticipate students being back in classrooms Monday.
About 750 flights were canceled at Chicago's O'Hare International Airport and about 300 flights were canceled at Midway, the Chicago Department of Aviation reported Friday morning.
Schools across MI cancelled classes.
Dozens of school districts - including the Milwaukee Public School District - were canceled in southern Wisconsin, the AP added. Michigan State Police said about 50 vehicles were involved in the Friday afternoon pileup in the highway's eastbound lanes just east of Kalamazoo.
Four major USA airlines - Delta, United, Frontier and Southwest - issued weather waivers for passengers, allowing travelers to change their reservations without incurring fees.
Meteorologist Heather Orow in Grand Rapids, Michigan, said Friday morning the storm is "generally going to be an issue for travel". Still, the city experienced dozens of vehicle crashes Thursday evening and early Friday.