It always appeared a case of when rather than if United would progress to the last-16 for the first time since 2013-14, despite their winning start to Group A ending with the last-gasp defeat at Basel.
Kylian Mbappe got one back for the Parisians who won the group and may go up against the likes of Chelsea, Juventus and Real Madrid in the last 16. Tottenham and Besiktas complete the set of current qualifiers.
Teams from the same group or country can not be drawn against one another.
Indeed, the changes implemented in time for next season, guaranteeing four group-stage spots for clubs from Spain, Germany, England and Italy, are really a step closer to a closed league for the elite.
Indeed, it may turn out that only two qualifiers come from outwith that elite, with Turkish champions Besiktas already through in Group G and only one of Basel or CSKA Moscow likely to advance in Group A.
Chelsea blew the opportunity to finish top of their group with a 1-1 draw with Atletico Madrid on Tuesday night at Stamford Bridge, with the draw allowing Roma to leapfrog them to finish as Group C winners. By Wednesday, it could have five.
Cesar Azpilicueta is aiming to put the disappointment of Chelsea's failure to top their Champions League group behind him and focus on the Blues' domestic commitments.
Bayern hosts Paris Saint-Germain today needing to win by a four-goal margin to progress as Group B victor.
The only outsiders to make it past the group stage last season were Portuguese giants Benfica and FC Porto.
Elsewhere, Roma recorded a 1-0 win over Qarabag at the Stadio Olimpico.
"We want to win and sing together", Di Francesco posted on social media.
Below, we examine the key Opta numbers behind Tuesday's clashes. But the only other team in the group that was any good - Napoli - fell apart and never mounted much of a challenge, ultimately finishing in third place behind Shakhtar Donetsk.