Sporting have been rejuvenated in the last two seasons under Jorge Jesus, but face the daunting task of having to win at Barcelona to have any chance of ending a nine-year absence from the knockout stage.
Besiktas have qualified as winners of Group G.
For the Russians to pip Basel to the other qualifying spot they need to better the Swiss club's result away to pointless Benfica.
Tottenham, Manchester City and Chelsea are all through to the second round of the competition. PSG are now in first place so Bayern must win by a four-goal margin to go through top.
Liverpool go into their final game one point ahead of second place Sevilla and three points ahead of Spartak Moscow.
Due to their superior head-to-head record against Real Madrid, Tottenham will qualify as winners of Group H.
Leipzig, who are level on points with Porto, host group victor Besiktas Wednesday and will only go through if they secure more points than the Portuguese team.
The teams who won their group will host the second leg of their round of 16 draws. Sevilla only need to draw with Maribor in Slovenia to qualify for the knockout stage, and would go through as group winners if they win and Liverpool slip up.
Qarabag will finish bottom of Group C. Coming off a devastating loss at home to Juventus in Serie A, the Partenopei must win at Feyenoord on Wednesday and hope Manchester City beats Shakhtar Donetsk in Group F.
But the focus on Tuesday's games will be on the fate of Atletico Madrid which hangs by the slenderest of threads.
Italian champions Juventus qualified from Group D after a 2-0 victory against Olympiakos in Greece, and Roma are through from Group C thanks to a 1-0 win at home to Qarabag.
"We want to win and sing together", Di Francesco posted on social media.
After putting seven goals past Celtic two weeks ago in Group B, PSG and its impressive offensive armada of Neymar, Kylian Mbappe and Edinson Cavani will also try to improve what is already a tournament record of 24 goals in this season's group stage.
But it heads to Athens on Tuesday still needing a win to definitely progress.