This marked the first time in franchise history Carolina has run for 200-plus yards in back-to-back games - last week the Panthers ran for 201 yards against Atlanta. The teams combined for three points, 106 yards, three penalties and three punts in the first quarter.
The Carolina Panthers put together by far their most complete game of the season on Monday night, as they obliterated the Dolphins, 45-21, in prime time to move to 7-3 on the season.
But somehow the Dolphins have managed to remain even at 4-4.
The offense, which entered averaging 14.5 points per game, worst in the National Football League, scored three touchdowns but two of those came in what could be considered desperation time.
Jonathan Stewart ran for a season-high 110 yards, and Newton had a 69-yard jaunt on a read option as the Panthers racked up 294 yards on the ground.
From there it only took four plays for Newton to find tight end Ed Dickson for a seven-yard touchdown pass with 24 seconds left that gave the Panthers a 17-7 halftime lead.
The Dolphins showed life when Kenyan Drake went 66 yards for a touchdown on a third-down run.
Newton's four touchdown passes were to three different receivers, including a pair to Devin Funchess.
Carolina, which was led by quarterback Cam Newton (254 passing yards, four touchdowns, 120.4 passer rating, 95 yards rushing) totaled 548 yards. Miami was never able to make the game competitive after that point. The result was a 10-play, 75-yard drive that ended with a two-yard shovel pass to tight end Julius Thomas.
Panthers centre Tyler Larsen suffered a foot injury and was questionable to return.