More booing too for 100m gold medal victor Justin Gatlin on his entry, who ran the second leg with the American team along with Mike Rodgers, Jaylen Bacon and Christian Coleman, who won the individual gold.
Since confirming his sprinting dominance with triple gold at the 2008 Beijing Olympics, Bolt spent nine seasons amassing 19 global golds, 13 of which have come in individual events. And Kevin Mayer is the new "world's greatest athlete".
The glitter that has cascaded upon Usain Bolt throughout his incredible career was nowhere to be seen in London, instead the eight-time Olympic champion was spiked with bad luck that led to a disaster.
But hopes were high for Bolt's final competitive race, with Jamaica also boasting McLeod, Forte and 2011 world champion Yohan Blake in their line-up. Another German, Kai Kazmirek, is in bronze-medal position with 7,796 points.
Rather than bemoaning a far from fitting end to the 30-year-old's distinguished career, the crowd inside London Stadium were lost in celebration for the victorious home nation.
Defending champion Ashton Eaton retired this year after winning the last two Olympic and world titles.
The United States ate up the track to run a world leading time in the women's 4x100 metres relay heats at the World Athletics Championships on Saturday.
It was less convincing, however, for the men's four, who progressed as fastest qualifiers into the final.
France and China also qualified.
Bolt took the baton in second, but pulled up shortly into his final 100-meter stretch.
A wheelchair was brought to his side before he was helped to his feet and managed to limp away, but it means he leaves his final championship with only a bronze from the individual 100m to show.
Felix has won 14 medals at the world championships and can move up to 16 if she runs the 4x400 relay and the United States win medals in both events.
The official result recorded that the Jamaicans did not finish but Bolt had been absolutely determined to ensure he completed the last race after a matchless career in which he won 19 major championship gold medals.
Even Usain Bolt's perceived rival Justin Gatlin conceded the drop in temperature had an affect.