Romero received a star on the Hollywood Walk of Fame a year ago.
Outside the undead, Romero also created Knightriders, a movie that imagines jousters re-enacting tournaments on motorcycles, and Creepshow, written by Stephen King. "Romero, being the creator of the "#Night Of The Living Dead", will always be known for his expertise with zombie film genres.
Condolences poured in from Hollywood after Romero's death was announced, including from action film director Zack Snyder, who made his feature film debut with the 2004 remake of "Dawn of the Dead". He will certainly be missed.
As reported by the L.A. Times, Romero's family announced Sunday that the filmmaker has passed away after a battle with lung cancer.
Romero's family confirms the news through a statement given by Chris Roe, Romero's manager, as stated in a report by NBC News.
His work was the inspiration to a number of later filmmakers such as Edgar Wright, who shot to fame in 2004 with zombie parody "Shaun of the Dead" starring Simon Pegg and Nick Frost.
Born in the Bronx, New York, in 1940 to a Cuban father and Lithuanian-American mother, Romero attended Carnegie Mellon University in Pittsburgh.
He co-wrote and directed the film that started the zombie series Night Of The Living Dead in 1968.
He is survived by his wife Suzanne and two children.
In 1978, he went back to the Zombie theme with the movie "Dawn of the Dead", which grossed more than $55 million.
Mr Romero's movies were about much more than just shuffling zombies: they took on racism, mall culture, class divides and militarism.